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==The casposases==
More recently, TE related to CRISPRs, Casposons have been identified<ref>{{#pmid:24884953</ref> and a reassement of their ends has led to the identification of an 14-15 bp target duplication. Moreover, the purified Cas1 enzyme encoded by these ancestral transposons has been demonstrated to catalyse strand transfer of a pre-cleaved transposon in vitro but does not appear to promote transposon strand cleavage in this assay<ref>{{#pmid:26573596</ref>. Cas1 "casposases" use similar chemistry to that used by the CRISPR Cas1-Cas2 complex but with opposite substrate specificities since CRISPR Cas1-Cas2 integrates "random" sequences into a specific site in the CRISPR locus whereas casposases integrate specific site (the casposon ends) into random target sequences [[:Image:1.44.png|(Fig.1.44)]].         

[[Image:1.44.png|thumb|center|510x510px|'''Fig 1.44.''' Organization of the ''A. boonei'' casposon. The casposon is shown as an unfilled box. Black filled arrow-heads represent the terminal inverted repeats (TIR); green arrows, the target site duplication (TSD); the genes areas follows: type B DNA polymerase (red box); HNH endonuclease (green); transcriptional regulator with HTH domain (pink); hypothetical protein with HTH domain (orange); cas1 (dark blue) with a c-terminal HTH (light blue); N6-methyltransferase (yellow). From Hickman and Dyda (2015). Non-CRISPR-associated cas1 form two distinct clades. One contains three distinct casposon families (1, 2 and 3) which share features with eukaryotic Polinton/Maverick eukaryotic transposons labelled ‘self-synthesizing’ since they include B family DNA polymerase genes. Members of the three families differ in gene content and evolutionary provenance of the DNA polymerases (protein-primed or RNA-primed).|alt=]]

==Bibliography==
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