General Information

Fig.1.1. The Busy Genome: Elements of Horizontal Exchange. The genome backbone, which includes housekeeping genes, is shown as the inner circle (blue). The "mobilome" is shown in the outer circle. This includes a number of different types of MGE both intercellular (some genomic islands, prophages, and conjugative transposons) and intracellular (Insertion sequences, compound and unit transposons, integrons, and super integrons). An important class of intercellular MGE, the plasmids, act as transposon vectors and facilitate TE movement within the plasmidome.

1. Overview 2. Insertion Sequence History and Early Transposition Models 3. What Is an IS? 4. ISfinder and the Growing Number of IS 5. IS Identification, nomenclature and naming attribution 6. IS Distribution 7. Major Groups are Defined by the Type of Transposase They Use 8. Fuzzy Borders 9. tIS - IS and relatives with passenger genes 10. IS derivatives of Tn3 family transposons 11. IS related to Integrative Conjugative Elements (ICEs) 12. IS91 and ISCR families 13. Non-autonomous IS derivatives 14. Relationship Between IS and Eukaryotic TE 15. Impact of IS on Genome Evolution - The Importance of Time Scale 16. Target Choice 17. Influence of transposition mechanisms on genome impact 18. IS and Gene Expression 19. IS Organization 20. Control of transposition activity 21. Transposase expression and activity 22. Reaction mechanisms 23. The Casposases

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