IS Families/ISAzo13 family: Difference between revisions

Revision as of 16:24, 10 June 2025

This family, represented by 37 members in ISfinder emerged from the ISNCY orphan group. It is based on both Tpase and IR sequence similarities (Fig.ISAzo13). Insertion generates a 3bp AT-rich DR and the ends have a consensus GGa/g. Their Tpases are highly conserved with a probable DDE motif and an HTH motif at the N-terminus which could function as a DNA binding domain. Two members encode two orfs with a possible PRF (Programmed Transcriptional Frameshifting) motif of 8 or 9 A while the other members encode a unique orf which includes a triple lysine at the equivalent position (Gourbeyre, unpublished)^[1].

**Fig. ISAzo13.** **General ISAzo13 characteristics, average length and common ends. Top:** Distribution of IS length (base pairs) of ISAzo13 family members. The number of examples used in the sample is shown above each column. **Bottom**: Left (**IRL**) and right **IRR** inverted terminal repeats are shown in WebLogo format.

Bibliography

↑ Siguier et al.. ISfinder: the reference centre for bacterial insertion sequences. Nucleic acids research. 2006. 34. pp. D32-6. doi: 10.1093/nar/gkj014. PMID: 16381877.

How to Cite?

Zenodo. TnCentral and TnPedia Team. (2025). TnPedia: ISXXXXXX Family of Prokaryotic Insertion Sequences. Zenodo. https://doi.org/XXXXXX/zenodo.YYYYYYYY

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[1] Siguier et al.. ISfinder: the reference centre for bacterial insertion sequences. Nucleic acids research. 2006. 34. pp. D32-6. doi: 10.1093/nar/gkj014. PMID: 16381877.

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+== How to Cite? ==
+Zenodo. TnCentral and TnPedia Team. (2025). TnPedia: IS''XXXXXX'' Family of Prokaryotic Insertion Sequences. Zenodo. https://doi.org/XXXXXX/zenodo.YYYYYYYY
+[[File:IS3-zenodo.YYYYYYYY.png|link=https://doi.org/XXXXXX/zenodo.YYYYYYYY|DOI badge]]
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TnPedia
General Information	Overview, IS History, What Is an IS?, ISfinder and the Growing Number of IS, IS Identification, IS Distribution, Major Groups are Defined by the Type of Transposase They Use, Fuzzy Borders, tIS - IS and relatives with passenger genes, IS derivatives of Tn3 family transposons, IS related to Integrative Conjugative Elements (ICEs), IS91 and ISCR, Non-autonomous IS derivatives, Relationship Between IS and Eukaryotic TE, Impact of IS on Genome Evolution - The Importance of Time Scale, Target Choice, Influence of transposition mechanisms on genome impact, IS and Gene Expression, IS Organization, Control of transposition activity, Transposase expression and activity, Reaction mechanisms, The casposases
Insertion Sequences	IS1 family, IS1595 family, IS3 family, IS481 family, IS1202 family, IS4 and related families, IS5 and related IS1182 families, IS6 family, IS21 family, IS30 family, IS66 family, IS110 family, IS256 family, IS630 family, IS982 family, IS1380 family, ISAs1 family, ISL3 family, ISAzo13 family, IS607 family, IS91-ISCR families, IS200-IS605 family, ISPa17 family
Transposable Elements	Compound transposons or composite transposons, Tn3 family, Tn7 family, Tn402 family, Tn554 family