IS Families

Organization of different insertion sequence (IS) -related derivatives. IS with DDE transposases (Tpases) and their derivatives are shown as blue boxes, Terminal Inverted Repeats as light blue triangles, and flanking direct target repeats as red boxes. The Tpase orfs are shown as black horizontal arrows. Passenger genes are shown as orange boxes and transfer functions (in the case of ICE) are shown as purple boxes. The single-strand IS are indicated with their left (red) and right (blue) subterminal secondary structures indicated. (A) IS organization. From top to bottom: a typical IS with a single Tpase orf; an IS in which the Tpase reading frame is distributed over two reading phases and requires frameshifting for expression; and the organization of a typical member of the single-strand IS family IS200/IS605. (B) Different IS-related TE. From top to bottom: composite transposon Tn10 with inverted flanking copies of IS10 (note that the left IS10 copy is not autonomously transposable); a unit transposon of the Tn3 family; and an integrative conjugative element (ICE). (C) Relationship between IS, Miniature Inverted Repeat Transposable Elements (MITE), transporter IS (tIS) and Mobile Insertion Cassettes (MIC). (D) Generation of Palindrome-Associated Transposable Elements (PATE) from IS200/IS605 family members. Extracted from Siguier et a., 2015.

++++ Prokaryotic elements ++++
1. IS1 family 2. IS1595 family 3. IS3 family 4. IS481 family 5. IS4 and related families 6. IS701 family 7. ISH3 family 8. ISH1634 family 9. IS5 and related IS1182 families 10. IS6 family 11. IS21 family 12. IS30 family 13. IS66 family 14. IS110 family 15. IS256 family 16. IS630 family 17. IS982 family 18. IS1380 family 19. ISAs1 family 20. ISL3 family 21. ISAzo13 family 22. IS200/IS605 family

++++ Eukaryotic elements ++++
23. hAT family 24. CACTA family 25. P family 26. Transib family 27. Sola family